Table 2.

Meta-regression – p-value for difference in 1- and 5-year risk of IBD-related hospitalization in patients with ulcerative colitis and Crohn’s disease, based on study-level factors using mixed effects meta-regression

	1y risk of hospitalization		5y risk of hospitalization
	Coefficient	p-value	Coefficient	p-value
Ulcerative colitis
Mean age at UC diagnosis	−0.061	0.05	−0.063	0.07
Proportion of males	0.015	0.69	0.031	0.42
Proportion of patients with extensive colitis	0.020	0.42	0.015	0.57
Mid-point of cohort entry	−0.009	0.78	−0.005	0.84
Crohn’s disease
Mean age at CD diagnosis	−0.034	0.61	−0.058	0.38
Proportion of females	−0.017	0.63	−0.009	0.69
Proportion of patients with ileum-dominant CD (L1/L3)	0.055	0.04	0.041	0.23
Proportion of patients with perianal CD	0.097	0.13	0.130	0.03
Proportion of patients with penetrating or stricturing CD	0.020	0.40	0.035	0.12
Mid-point of cohort entry	−0.084	0.02	−0.062	0.01

[Abbreviations: B1/B3=ileal of ileocolonic location based on Montreal classification; CD=Crohn’s disease; UC=ulcerative colitis]