Table 1.

Summary of average number of epitopes in the Wuhan-1 and Omicron spike protein sequences predicted for HLA class I and II alleles including in the 12 and 10 HLA class I or class II supertypes, resepctively.

HLA superfamily	Number of epitopes (mean ± SEM)		Vaccines/Omicron p-value
	Vaccines	Omicron
A01	14.9 ± 1.4	13.7 ± 1.3	n.s.
A0103	6.3 ± 1.8	5.3 ± 1.5	n.s.
A0124	24.1 ± 1.9	21.6 ± 1.7	n.s.
A02	18.7 ± 1.0	15.3 ± 0.9	<0.5
A03	22.6 ± 1.6	17.5 ± 1.1	<0.01
A24	38.7 ± 2.1	32.7 ± 1.8	<0.5
B07	11.2 ± 1.0	10.5 ± 1.0	n.s.
B08	5.8 ± 0.9	5.8 ± 0.9	n.s.
B27	11.3 ± 1.7	9.2 ± 1.4	n.s.
B44	9.9 ± 0.6	8.8 ± 0.5	n.s.
B58	19.4 ± 3.2	18.9 ± 3.1	n.s.
B62	14.7 ± 1.6	11.8 ± 1.2	n.s.
DR1	12.5 ± 0.9	12.1 ± 0.8	n.s.
DR52	21.0 ± 1.0	19.5 ± 0.5	n.s.
DR53	11.0 ± 3.1	10.8 ± 3.2	n.s.
DP1	16.0 ± 0.9	15.8 ± 0.8	n.s.
DP3	13.0 ± 1.0	12.5 ± 0.5	n.s.
DQ2	9.0 ± 1.0	9.0 ± 1.0	n.s.
DQ4	14.0 ± 1.4	13.8 ± 1.6	n.s.
DQ5	11.7 ± 2.3	11.7 ± 2.3	n.s.
DQ7	11.4 ± 1.0	11.2 ± 1.1	n.s.
DQ8	13.5 ± 0.5	13.5 ± 0.5	n.s.

ns, not significant.