Table 1.
The roles of different m6A regulators in regulating RNAs in cervical cancer.
| m6A regulators | Genes/RNAs | Cell lines | Location | Role | Mechanism | Function | References |
|---|---|---|---|---|---|---|---|
| YTHDF1 | RANBP2 | HEK293T, Hela, SiHa | mRNA | Oncogene | Enhance expression of RANBP2 | Promote cervical cancer tumorigenesis and metastasis | (26) |
| METTL3 | HK2 | CaSki, SiHa, C33A, HT-3, HaCaT | mRNA | Oncogene | Enhance expression of HK2 | Promote cervical cancer tumorigenesis and aerobic glycolysis | (61) |
| FTO | β-catenin | SiHa, c-33a | mRNA | Oncogene | down-regulated expression of β-catenin | Enhance the activity of ERCC1 | (62) |
| METTTL3 | PDK4 | HeLa, SiHa, Huh7, HepG2, MDA-MB-231, ECT1/E6E7 | mRNA | Oncogene | TBP promotes the expression of METTL3 | Regulating glycolysis in cancer cells | (63) |
| IGF2BP2 | circARHGAP12 | HaCaT, HT-3, CaSki, C33A, SiHa | CircRNA | Oncogene | Enhanced the stability of FOXM1 mRNA | Promote cervical cancer tumorigenesis and metastasis | (64) |
| METTTL3 | circ_0000069 | SiHa, Caski, C33A, Ect1, 293T | CircRNA | Oncogene | Inhibit the expression of miR-4426 | Promote cervical cancer tumorigenesis and metastasis | (65) |
| ALKBH5 | LncRNA GAS5-AS1 | Caski, SiHa, C33A, HeLa, HCvEpC | LncRNA | Tumor suppressor | Decreasing GAS5 N6-methyladenosine m(6)A modification | Reduced cervical cancer tumorigenesis and metastasis | (66) |
| IGF2BP3 | KCNMB2-AS1 | SiHa, HeLa, | LncRNA | Oncogene | KCNMB2-AS1 competed with miR-130b-5p and miR-4294 and up-regulated IGF2BP3 | Promote cervical cancer tumorigenesis and metastasis | (67) |
| METLL3 | ZFAS1 | Hela, SiHa, C33A, CaSki, 293T | LncRNA | Oncogene | ZAFS1 sequestered miR-647 and regulated by METLL3 | Promote cervical cancer tumorigenesis and metastasis | (68) |
| METLL3 | miR-193b | Siha, Hela | miRNA | Tumor suppressor | By targeting CCND1 | Reduced cervical cancer tumorigenesis and metastasis | (69) |