Table 2.
The roles of different m6A regulators in regulating RNAs in endometrial cancer.
| m6A regulators | Genes/RNAs | Cell lines | Location | Role | Mechanism | Function | References |
|---|---|---|---|---|---|---|---|
| ALKBH5 | IGF1R | HEC-1-A, RL95-2, T-HESCs | mRNA | Oncogene | Enhance expression of IGF1R | Promote endometrial cancer tumorigenesis and metastasis | (27) |
| FTO | HOXB13 | AN3CA, KLE | mRNA | Oncogene | Enhance expression of HOXB13 and activate the WNT signaling pathway | Promote endometrial cancer tumorigenesis and metastasis | (86) |
| YTHDF2 | IRS1 | HEC-1-A, RL95-2, T-HESCs | mRNA | Tumor suppressor | Degrade IRS1 mRNA, Inhibition of IRS1/AKT signaling pathway | Inhibit the tumorigenicity of endometrial carcinoma | (88) |
| IGF2BP1 | PEG10 | Ishikawa, HEC-1-A, HEC-1-B, RL-95-2, AN3CA, KLE | mRNA | Oncogene | Enhance expression of PEG10 | Promote endometrial cancer tumorigenesis and metastasis | (90) |
| IGF2BP1 | SOX2 | Ishikawa, ECC-1, HEK293 | mRNA | Oncogene | Enhance expression of SOX2 | Promote endometrial cancer tumorigenesis and metastasis | (91) |
| YTHDF2 | FENDRR | Ishikawa, HEC-1-B | LncRNA | Oncogene | Degrade LncRNA FENDRR | Promote endometrial cancer tumorigenesis and metastasis | (92) |