Table 2.

Clinical factors related to CRS.

Clinical factor	Total cohort (n = 25)	Grade 1-2 (n = 17)	Grade 3-5 (n = 8)	p value*
Fulfill SIRS criteria	25 (100.0)	17 (68.0)	8 (32.0)	N.A.
Age	64.0 (55.0-74.5)	64.0 (56.5-70.0)	66.5 (48.8-81.3)	0.560
Gender (male)	18 (72.0)	11 (64.7)	7 (87.5)	0.236
BMI	22.8 (18.0-25.8)	23.7 (17.7-26.4)	22.0 (19.3-23.6)	0.483
Days to fever	11.0 (0.0-24.0)	3.0 (0.0-18.0)	25.0 (13.0-136.5)	0.027
Dual ICI (anti-CTLA-4/anti-PD-1)	4 (16.0)	2 (11.8)	2 (25.0)	0.400
Duration of CRS (days)	15.0 (6.3-29.8)	11.5 (7.3-27.5)	22.0 (2.0-31.5)	0.902
Frequency of CRS episodes				0.861
Single	15 (60.0)	10 (58.8)	5 (62.5)
Multiple	10 (40.0)	7 (41.2)	3 (37.5)
Other concomitant irAEs				0.319
No	12 (48.0)	7 (41.2)	5 (62.5)
Yes	13 (52.0)	10 (58.8)	3 (37.5)
Grade 3 or more concomitant irAEs	3 (12.0)	2 (11.8)	1 (12.5)	0.837
Positive microbiological cultures	1 (4.0)	1 (5.9)	0 (0.0)	0.484
Antibiotics	20 (80.0)	12 (70.6)	8 (100.0)	0.121
CRS toxicities by organ system
Cardiovascular	8 (32.0)	2 (11.8)	6 (75.0)	0.002
Dermatological	7 (28.0)	6 (35.3)	1 (12.5)	0.236
Gastrointestinal	9 (36.0)	7 (41.2)	2 (25.0)	0.432
Hepatic	10 (40.0)	6 (35.3)	4 (50.0)	0.484
Neurological	4 (16.0)	0 (0.0)	4 (50.0)	0.001
Pulmonary	4 (16.0)	1 (5.9)	3 (37.5)	0.044
Renal	4 (16.0)	3 (17.6)	1 (12.5)	0.743
Rheumatic	6 (24.0)	2 (11.8)	4 (50.0)	0.037
CRS grade-defining events
Hypotension	8 (32.0)	2 (11.8)	6 (75.0)	0.002
High-dose vasopressors used	3 (12.0)	0 (0.0)	3 (37.5)	0.007
Oxygen supplementation	20 (80.0)	13 (76.5)	7 (87.5)	0.520
Intubation	3 (12.0)	0 (0.0)	3 (37.5)	0.007
ICU admission	4 (16.0)	0 (0.0)	4 (50.0)	0.001

*Comparison between Grades 1-2 and 3-5 CRS.

SIRS, systemic inflammatory response syndrome; BMI, body mass index; ICU, intensive care unit.

Data are frequency (%) or median (interquartile range).

Bold characters in Tables are to emphasize p values < 0.05.