Table 1.
Clinical characteristics and summary results of 4 weeks of DIY-APS usage
| Variable | Overall | Daytime (6:00 AM to 12:00 AM) | Nighttime (12:00 AM to 6:00 AM) | P value |
|---|---|---|---|---|
| No. of participants | 10 | - | - | - |
| Age, yr | 10.1±3.2 | - | - | - |
| Male/Female | 7 (70.0)/3 (30.0) | - | - | - |
| Weight, kg | 33.0±11.9 | - | - | - |
| BMI, kg/m2 | 17.2±2.4 | - | - | - |
| Duration of diabetes, yr | 3.1 (1.8 to 6.5) | - | - | - |
| HbA1c, % | 6.2±0.3 | - | - | - |
| Duration of DIY-APS usage, yr | 1.9±1.1 | - | - | - |
| Average glucose level, mg/dL | 135.8±11.92 | 137.78±12.48 | 130.01±13.74 | 0.017 |
| % CV of glucose | 31.57±4.43 | 31.43±4.7 | 28.46 (27.05 to 33.75) | 0.799 |
| TAR >250 mg/dL, % | 1.01 (0.65 to 2.39) | 1.18 (0.73 to 2.61) | 0.79 (0.08 to 2.49) | 0.333 |
| TAR >180 mg/dL, % | 14.77±7.85 | 14.34 (11.96 to 16.55) | 12.16±7.08 | 0.093 |
| TIR 70–180 mg/dL, % | 82.8±8.12 | 82.31±9.06 | 84.14± 6.78 | 0.799 |
| TBR <70 mg/dL, % | 2.42±1.39 | 2.0±1.27 | 3.7±3.33 | 0.074 |
| TBR <54 mg/dL, % | 0.65±0.5 | 0.45 (0.13 to 1.01) | 0.49 (0.19 to 1.66) | 0.445 |
| Hypoglycemic events | ||||
| <70 mg/dL, n/day | 0.76±0.41 | 0.53±0.32 | 0.24±0.15 | 0.011 |
| <54 mg/dL, n/day | 0.21±0.16 | 0.11 (0.08 to 0.28) | 0.04 (0.01 to 0.09) | 0.035 |
| Prolonged, n/day | 0 (0 to 0.03) | 0 | 0 | 1.000 |
| GMI, % | 6.56±0.29 | 6.61±0.3 | 6.42±0.33 | 0.017 |
| TDD, unit/kg/day | 0.79±0.16 | 0.66 (0.62 to 0.73) | 0.09±0.02 | 0.005 |
| Basal, % | 42.25±7.57 | 37.07±7.88 | 86.16±8.91 | 0.005 |
| Bolus, % | 57.75±7.57 | 62.93±7.88 | 13.84±8.91 | 0.005 |
| Median temporary basal | ||||
| Per hour, % | –21.42 (–23.25 to –17.92) | –23.44±8.98 | –10.65±25.32 | 0.386 |
| Per day, % | –10.94±11.1 | |||
| Frequency of basal changes, n/hr | 2.05 (1.97 to 2.13) | 2.26 (2.19 to 2.37) | 1.58 (1.52 to 1.72) | 0.005 |
| Bolus, n/day | 11.8±3.12 | 11.1±3.08 | 0.5 (0.43 to 0.88) | 0.005 |
Values are presented as mean±standard deviation, number (%), or median (interquartile range).
DIY, do-it-yourself; APS, artificial pancreas system; BMI, body mass index; HbA1c, glycosylated hemoglobin; CV, coefficient of variation; TAR, time above range; TIR, time in range; TBR, time below range; GMI, glucose management indicator; TDD, total daily insulin dose.