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Study design. The participants were randomly assigned to either the Implementing New Strategies with Insulin Glargine for Hyperglycemia Treatment (INSIGHT) or EDITION group and self-titrated the dose of insulin glargine 300 units/mL according to each algorithm for 12 weeks. NIAHA, noninsulin antihyperglycemic agents; NPH, neutral protamine Hagedorn; SMBG, self-monitoring of blood glucose. aIn group 2, one individual was excluded owing to the withdrawal of informed consent.
