Table 1.

Definitions of AKI by ICA and diagnostic criteria of HRS-AKI.

	Definition
Baseline SCr	Baseline serum creatinine (SCr) was defined as value obtained in the previous 3 months. In patients with more than one value, the one closest to the admission time should be used. In patients without, the serum creatinine on admission should be used as baseline.
AKI definition	Increase in SCr ≥0.3 mg/dl (26.5 μmol/L) within 48 h; or, A percentage increase SCr ≥50% from baseline which is known, or presumed, to have occurred within the prior 7 days
AKI stage	• Stage 1: increase in SCr ≥0.3 mg/dl (26.5 μmol/L) or an increase in SCr ≥ 1.5-fold to 2-fold from baseline • Stage 2: increase in SCr >2-fold to 3-fold from baseline • Stage 3: increase in SCr >3-fold from baseline or SCr ≥4.0mg/dl (353.6 μmol/L) with an acute increase ≥0.3 mg/dl (26.5 μmol/L) or initiation of renal replacement therapy
Diagnostic criteria of HRS-AKI	• Diagnosis of AKI according to ICA AKI criteria • Cirrhosis with ascites • No response after two consecutive days of diuretic withdrawal and plasma volume expansion with albumin • Absence of shock • No current or recent use of nephrotoxic drugs (NSAIDs, aminoglycosides, iodinated contrast media, etc.) • No macroscopic signs of structural kidney injury, as followings:     • Absence of proteinuria (>500 mg/day)     • Absence of microhaematuria (>50 RBCs per high power field)     • Normal findings on renal ultrasonograpgy

AKI, acute kidney injury; ICA, International Club of Ascites; HRS, hepatorenal syndrome; SCr, serum creatinine; NSAIDs, non-steroidal anti-inflammatory drugs; RBCs, red blood cells.