FIGURE 2.

Mettl3 induced upregulation of m⁶A methylation level in myocardial tissue, H9c2 cells, and HUVECs. (A) m⁶A methylation level of MI rat and hypoxic cells; (B) expression of m⁶A methylation enzymes in myocardial tissue samples and cells by qRT-PCR; (C) number of peaks in the SO and MI group; (D) volcano plots for differentially methylated m⁶A peaks; (E) distribution of differentially methylated m⁶A peaks in the SO and MI group; (F) distribution patterns of differentially m⁶A methylated peaks on chromosomes; (G) sequence motif for the m⁶A peak regions. UTR, untranslated region; Exon, expressed region; SO, sham operated; MI, myocardial infarction. *p < 0.05.