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. 2022 Jan 28;8:789923. doi: 10.3389/fmolb.2021.789923

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Copyright © 2022 Zhang, Hua, Dang, Cheng, Wang, Zhang, Teng, Wang, Zhang, Kong, Lu and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hub mRNAs associated with angiogenesis and apoptosis. (A) Volcano plots for differentially expressed mRNAs; (B) heatmap plots for differentially expressed mRNAs; (C) four-quadrant graph for m⁶A methylation regulated mRNAs; (D) Venn diagram showing the relationships between m⁶A methylation and mRNAs expression; (E) validation of the top 10 hypermethylated and downregulated mRNAs in MI rats; (F) Venn diagram showing the relationship between hub mRNAs and apoptosis/angiogenesis. Hypo-Up, hypomethylated and upregulated; hyper-Up, hypermethylated and upregulated; Hypo-Down, hypomethylated and downregulated; hyper-Down, hypermethylated and downregulated. SO, sham operated; MI, myocardial infarction. *p < 0.05, **p < 0.01, ***p < 0.001.