Table 2.

Comparison of IVIM-DWI parameters between the control and treated groups at different time points before and after antiangiogenic therapy.

	Day 0	Day 1	Day 3	Day 5	Day 7
ADC (×10−3 mm2/s)
Control	0.585 ± 0.112	0.577 ± 0.126	0.487 ± 0.130	0.450 ± 0.150	0.363 ± 0.140
Treated	0.643 ± 0.290	0.668 ± 0.271	0.733 ± 0.182	0.846 ± 0.278	0.968 ± 0.340
p	0.215	0.055	0.033	<0.001	<0.001
D (×10−3 mm2/s)
Control	0.274 ± 0.052	0.268 ± 0.040	0.192 ± 0.087	0.145 ± 0.058	0.086 ± 0.039
Treated	0.288 ± 0.050	0.265 ± 0.064	0.396 ± 0.150	0.499 ± 0.016	0.630 ± 0.290
p	0.730	0.798	0.052	<0.001	<0.001
D* (×10−3 mm2/s)
Control	5.797 ± 1.642	5.946 ± 1.620	7.233 ± 2.760	8.189 ± 2.830	9.061 ± 1.870
Treated	6.374 ± 1.730	5.758 ± 1.450	4.446 ± 1.709	3.475 ± 1.440	3.290 ± 1.102
p	0.505	0.810	0.005	<0.001	<0.001
f (%)
Control	65.833 ± 11.502	59.837 ± 14.230	68.440 ± 22.003	69.164 ± 22.340	80.335 ± 28.037
Treated	69.525 ± 11.320	67.325 ± 12.530	59.355 ± 20.026	55.329 ± 24.703	44.858 ± 14.930
p	0.581	0.368	0.498	0.304	0.008

Comparisons of IVIM-DWI parameters between the control and treated groups at the same time point were performed by the independent-samples t-test.

ADC, apparent diffusion coefficient; D, diffusion coefficient; D*, pseudodiffusion coeffificient; f, perfusion fraction.