FIGURE 2.
FGF‐8‐related signalling pathway. (A) The binding of FGF‐8 molecules to FGFR activates a series of signalling pathways, such as PI3K/AKT, PLCγ/Ca2+, RAS/MAPK, MEK‐ERK and Wnt‐β‐catenin‐Axin2. (B) The MAPK‐ERK‐MEK pathway and Wnt signalling pathway induced by FGF‐8 signalling exert both promoting and inhibitory effects and jointly coordinate angiogenesis, tissue development and hormone regulation in the body. (C) The Wnt signalling pathway and JNK signalling pathway also interact through the activation of FGF‐8 signalling pathway