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. 2022 Jan 28;13:811045. doi: 10.3389/fimmu.2022.811045

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Copyright © 2022 Štorkánová, Oreská, Špiritović, Heřmánková, Bubová, Kryštůfková, Mann, Komarc, Slabý, Pavelka, Šenolt, Zámečník, Vencovský and Tomčík

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Plasma Hsp90 levels were increased in patients with IIM compared to healthy controls and were associated with serum markers of muscle damage. (A) Systemic levels of Hsp90 are significantly elevated in patients with idiopathic inflammatory myopathies (IIM) and individual subtypes of IIM (PM, polymyositis; DM, dermatomyositis; CDM, cancer-associated dermatomyositis and IMNM, immune-mediated necrotizing myopathy) compared to healthy controls (HC). Horizontal bars represent the median. Increased plasma Hsp90 is associated with elevated serum levels of (B) lactate dehydrogenase (LD) and (C) aspartate aminotransferase (AST).