Table 5.
Cytokines and chemokines involved in the pathogenesis of IIM and their correlation to plasma Hsp90 based on the bivariate analysis in all IIM patients (n=277).
| Cytokine/Chemokine | Spearman’s r | p-value |
|---|---|---|
| Interleukin 1β | 0.188 | 0.002 |
| Interleukin 6 | 0.182 | 0.003 |
| Interleukin 8 | 0.242 | <0.001 |
| Interleukin 17 | 0.201 | 0.001 |
| Interferon γ | 0.229 | <0.001 |
| C-X-C motif chemokine ligand 10 (CXCL10) | 0.224 | 0.001 |
| Monocyte chemoattractant protein 1 (CCL2) | 0.161 | 0.007 |
| Macrophage inflammatory protein 1-α (CCL3) | 0.208 | <0.001 |
| Macrophage inflammatory protein 1-β (CCL4) | 0.229 | <0.001 |
| Vascular endothelial growth factor | 0.260 | <0.001 |
| Platelet-derived growth factor-BB | 0.426 | <0.001 |
IIM, idiopathic inflammatory myopathies.