FIGURE 2.

Potential mechanisms by which developmental exposure to environmental endocrine disruptors may induce disease or dysfunction. EDCs may act as steroid agonists or antagonists by binding receptors and interfering with downstream responses. EDCs may also act via non-genomic mechanisms via binding to G-protein coupled receptors. Finally, interference with steroid action can promote inflammation via a variety of mechanisms, including the failure to curtail production of reactive oxygen species. Created with BioRender.com.