TABLE 3.
Dry-weight metal concentrations in hippocampus of VaD and control brains.
| Element | Concentration unit | Reference isotope | Control | VaD | Mann–Whitney U p-value | Welch’s t test p-value* |
| Na | mmol/kg wet weight | 23Na | 471 (403–538) | 609 (495–722) | 0.035 | 0.024 |
| Mg | mmol/kg wet weight | 24Mg | 28 (27–29) | 29 (28–31) | Ns | ns |
| K | mmol/kg wet weight | 39K | 321 (291–351) | 304 (273–336) | Ns | ns |
| Ca | mmol/kg wet weight | 44Ca | 11.3 (9.1–13.4) | 16.4 (7.0–25.8) | Ns | ns |
| Mn | μmol/kg wet weight | 55Mn | 28 (24–31) | 29 (23–36) | Ns | ns |
| Fe | mmol/kg wet weight | 56Fe | 4.10 (3.47–4.73) | 4.25 (3.67–4.84) | Ns | ns |
| Cu | μmol/kg wet weight | 63Cu | 276 (241–318) | 334 (289–379) | 0.052 | 0.0497 |
| Zn | μmol/kg wet weight | 66Zn | 1,278 (1,122–1,433) | 1,514 (1,322–1,705) | 0.089 | 0.0498 |
| Se | μmol/kg wet weight | 78Se | 9.81 (9.11–10.51) | 12.27 (7.49–17.05) | Ns | ns |
Data are means (± 95% CI); p-values for significance of between-group differences were calculated by Mann–Whitney U and Welch’s t test based on non-log transformed dry-weight measurements from control (n = 10) and VaD (n = 10) brains.
*Data were log10 transformed prior to parametric analysis and then back transformed to reflect the actual elemental concentrations.