Table 3.
GLMs for the Association Between NfL and Cognitive Function Measured by WCST a
| B | Std. Error | t | P | |
|---|---|---|---|---|
| WCST: percent perseverative errors | ||||
| Intercept | −42.181 | 22.927 | −1.840 | .070 |
| Education | −0.494 | 0.261 | −1.897 | .062 |
| Log TNF-α | 15.932 | 8.058 | 1.977 | .052 |
| NfL | −0.004 | 0.060 | -0.064 | .949 |
| WCST: percent conceptual level responses | ||||
| Intercept | 216.760 | 53.997 | 4.014 | <.001 |
| Education | 0.540 | 0.614 | 0.881 | .382 |
| Log TNF-α | −44.328 | 18.979 | −2.336 | .023 |
| NfL | −0.198 | 0.142 | −1.399 | .166 |
| WCST: no. of categories completed | ||||
| Intercept | 17.903 | 4.702 | 3.807 | <.001 |
| Education | 0.027 | 0.053 | 0.509 | .612 |
| Log TNF-α | −4.199 | 1.653 | −2.541 | .013 |
| NfL | −0.025 | 0.012 | −2.023 | .047 |
| WCST: trials to complete first category | ||||
| Intercept | −133.233 | 73.234 | −1.819 | .073 |
| Education | −1.226 | 0.832 | −1.473 | .145 |
| Log TNF-α | 47.526 | 25.740 | 1.846 | .069 |
| NfL | 0.615 | 0.192 | 3.200 | .002 |
Abbreviations: BMI, body mass index; GLM, general linear model; HDRS, 17-item Hamilton Depression Rating Scale; NfL, neurofilament light chain; TNF, tumor necrosis factor; WCST, Wisconsin Card Sorting Task.
a Adjusted for age, sex, group, education, BMI, TNF-α levels and HDRS total scores.