Fig. 2.

Subcellular localization and putative functions of VPS13A and XK.aThe VPS13A protein (chorein) localizes at membrane contact sites between the endoplasmic reticulum and mitochondria or lipid droplets, respectively.bVPS13A seems to function as bulk lipid transporter between membranes. Putative partner proteins include scramblases (possibly XK among them) that translocate phospholipids between the two sheets of the membranes tethered by VPS13A. Contains modified images from Servier Medical Art (https://smart.servier.com) licensed by a Creative Commons Attribution 3.0 Unported License.