Table 4. Outcomes of Patients Taking a NOAC Who Had an Acute Ischemic Stroke and Received Intravenous Alteplase in the ARAMIS Registry.
| No. (%) of patients who had an acute ischemic stroke by timing of last NOAC dose prior to strokea | ||||
|---|---|---|---|---|
| Overall (n = 47) | 0-24 h ago (n = 8) | 0-48 h ago (n = 25) | >48 h ago (n = 22) | |
| Primary outcome | ||||
| Symptomatic intracranial hemorrhage within 36 h | 2 (4.3) | 0 | 2 (8.0) | 0 |
| Secondary outcomes | ||||
| Life-threatening or serious systemic hemorrhage within 36 h | 0 | 0 | 0 | 0 |
| Any alteplase complicationb | 3 (6.4) | 0 | 3 (12.0) | 0 |
| Inpatient mortality | 2 (4.3) | 0 | 1 (4.0) | 1 (4.6) |
| In-hospital mortality or discharged to hospice | 4 (8.5) | 0 | 2 (8.0) | 2 (9.1) |
| Able to ambulate independently at hospital dischargec | 28/45 (62.2) | 5/8 (62.5) | 12/24 (50.0) | 16/21 (76.2) |
| Free of disabilities (modified Rankin Scale score of 0-1 at hospital discharge)d | 14/40 (35.0) | 1/7 (14.3) | 4/21 (19.0) | 10/19 (52.6) |
| Functionally independent (modified Rankin Scale score of 0-2 at hospital discharge)d | 17/40 (42.5) | 2/7 (28.6) | 6/21 (28.6) | 11/19 (57.9) |
| Discharge location | ||||
| Home | 26 (55.3) | 5 (62.5) | 10 (40.0) | 16 (72.7) |
| Hospice | 2 (4.3) | 0 | 1 (4.0) | 1 (4.5) |
| Inpatient rehabilitation facility | 11 (23.4) | 2 (25.0) | 7 (28.0) | 4 (18.2) |
| Skilled nursing facility | 6 (12.8) | 1 (12.5) | 6 (24.0) | 0 |
| Hospital length of stay >4 d | 19 (40.4) | 3 (37.5) | 14 (56.0) | 5 (22.7) |
Abbreviations: ARAMIS, Addressing Real-world Anticoagulant Management Issues in Stroke; NOAC, non–vitamin K antagonist oral anticoagulant.
These data are from a subset of patients participating in the ARAMIS registry. The reported date and time that the patient last took their anticoagulant medication was used to generate the time epochs; however, if the exact date and time was not available, the response to the question “Did patient stop anticoagulant medication >2 days prior to stroke onset?” was alternatively used to define the time epochs of less than 48 hours and greater than 48 hours.
Includes symptomatic intracranial hemorrhage within 36 hours, life-threatening or serious systemic hemorrhage within 36 hours, or other serious complications (those that required additional medical interventions or prolonged length of stay).
Data are expressed as No./total (%).
Data are expressed as No./total (%). The modified Rankin Scale has a score range of 0 to 6 with 0 being no symptoms; 1, no significant disability; 2, slight disability; 3, moderate disability; 4, moderately severe disability; 5, severe disability; and 6, death.