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. 2021 Dec 17;43(1):12–20. doi: 10.1093/carcin/bgab111

Figure 1.

Figure 1.

Effect on cell viability and colony formation efficiency by silencing TBX1 expression in breast cancer cells. (A) MDA-MB-231, MCF-7 and T47D cells were transfected with three TBX1 siRNAs (siTBX1-01, siTBX1-02, siTBX1-03), negative control siRNA (NC) and positive control siRNA (PC) for 96 h. Relative cell viability was normalized to NC group and expressed as percent (%) of control. Bar chart presented as mean ± SD from three independent experiments. (B) Colony formation (CF) ability of MDA-MB-231, MCF-7 and T47D cells transfected with three TBX1 siRNAs (siTBX1-01, siTBX1-02, siTBX1-03), NC siRNA and PC siRNA, respectively. The CFE was normalized to NC siRNA group and expressed as percent (%) of control. All the experiments were repeated three times independently and presented as mean ± SD. P-values were determined by one-way ANOVA followed by Dunnett’s multiple comparisons test. * P-value < 0.05, ** P-value < 0.01.