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. 2021 Dec 9;43(1):28–39. doi: 10.1093/carcin/bgab118

Figure 1.

Figure 1.

De novo synthesis of GCs in HNSCC cells. (A) De novo biosynthesis of cortisol/corticosterone from cholesterol. (B) Gene expression analysis of CYP11A1, HSD3B, CYP21A2, CYP17A1 and CYP11B1 in CAL27, SCC83, CA83, SCC15, UMSCC6, UMSCC22A oral cancer cell lines and TE1177 normal oral epithelial cell line, induced with ACTH (10 nM) for 24 h (N = 4 per group each from two independent experiments). Gene expression profile of the enzymes from the de novo synthesis pathway—Cyp11a1, Cyp21a2, Cyp17a1 and Cyp11b1 from 4NQO-exposed or control (C) F344 rats (N = 5–9 per group) and (D) C57BL/6 mice (N = 5–7 per group). Data are presented as mean ± SE.