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. 2021 Dec 9;43(1):28–39. doi: 10.1093/carcin/bgab118

Figure 2.

Figure 2.

Characterization of hydroxysteroid dehydrogenases expression and GC interconversion during oral carcinogenesis. (A) Representation of the interconversion between cortisol and cortisone by HSD11B1 and HSD11B2. (B) RNA level expression of HSD11B1 and HSD11B2 in CAL27, SCC83, CA83, SCC4, SCC9, SCC15, UMSCC6, UMSCC22A oral cancer cell lines and TE1177 normal oral epithelial cell line (N = 4 per group each from two independent experiments). (C) Representative western blot showing the expression of HSD11B2 in CAL27, SCC83 and CA83 oral cancer cells along with quantification of the bands for HSD11B2 (N = 3 per group from two independent experiments). (D) mRNA normalized counts of HSD11B1 and HSD11B2 in tumors and adjacent normal tissues of 550 clinical oral cancer patients from TCGA data. Gene expression of Hsd11b1 and Hsd11b2 in tongues of 4NQO-exposed (E) F344 rats (N = 5–9 per group) and (F) C57BL/6 mice (N = 5–7 per group). Data are presented as mean ± SE *P < 0.05 and ***P<0.001, respectively.