Table 2.

Multivariable models

Variable	OS HR (95% CI)	EFS HR (95% CI)	CR or CRi OR (95% CI)	RFS if CR/CRi HR (95%CI)
WHO AML (ref MDS-EB2)	0.89 (0.74-1.07)	0.89 (0.75-1.06)	1.06 (0.99-1.13)	0.66 (0.53-0.83)
P	.21	.2	.11	<.001
Age (per 10 y)	1.3 (1.22-1.38)	1.19 (1.13-1.26)	0.98 (0.96-1)	1.13 (1.05-1.2)
P	<.001	<.001	.02	<.001
PS 2-4 (ref PS 0-1)	2 (1.68-2.37)	1.68 (1.42-1.99)	0.87 (0.82-0.93)	1.21 (0.96-1.51)
P	<.001	<.001	<.001	.11
ELN 2017 intermediate risk (ref favorable risk)	1.7 (1.34-2.15)	1.72 (1.38-2.14)	0.86 (0.8-0.93)	2.15 (1.67-2.76)
P	<.001	<.001	<.001	<.001
ELN 2017 adverse risk (ref favorable risk)	2.28 (1.8-2.88)	2.29 (1.84-2.85)	0.78 (0.73-0.84)	3.07 (2.35-4)
P	<.001	<.001	<.001	<.001
Secondary (ref de novo)	1.3 (1.1-1.55) P = 0.002	1.28 (1.08-1.5) P = 0.004	0.93 (0.87-0.99) P = 0.02	1.16 (0.93-1.43) P = 0.18
P	.002	.004	.02	.18
Low-intensity induction (ref high intensity)	1.3 (1.08-1.55)	1.62 (1.36-1.93)	0.7 (0.66-0.75)	1.07 (0.82-1.38)
P	.004	<.001	<.001	.63
Allogeneic HCT (ref no allogeneic HCT)	0.48 (0.39-0.6)	0.39 (0.31-0.47)	Not applicable	0.29 (0.23-0.36)
P	<.001	<.001		<.001

Time-dependent Cox regression for OS, EFS, and RFS; logistic regression for CR/CRi and CR_MRD−.

HR, hazard ratio; OR, odds ratio.