Table 3.
Multivariable models
| Variable | CRMRD− OR (95% CI) | RFS if CRMRD− HR (95% CI) |
|---|---|---|
| WHO AML (ref = MDS EB2) | 1.13 (1.05-1.21) | 0.8 (0.56-1.15) |
| P | <.001 | .23 |
| Age (per 10 y) | 0.97 (0.95-0.99) | 1.18 (1.08-1.3) |
| P | .004 | <.001 |
| PS 2-4 (ref PS 0-1) | 0.92 (0.86-0.98) | 1.12 (0.82-1.53) |
| P | .01 | .48 |
| ELN 2017 intermediate risk (ref favorable risk) | 0.82 (0.75-0.88) | 2.14 (1.57-2.93) |
| P | <.001 | <.001 |
| ELN 2017 adverse risk (ref favorable risk) | 0.71 (0.65-0.77) | 2.58 (1.8-3.7) |
| P | <.001 | <.001 |
| Secondary (ref de novo) | 0.88 (0.82-0.94) | 0.85 (0.61-1.18) |
| P | <.001 | .33 |
| Low-intensity induction (ref high intensity) | 0.76 (0.71-0.82) | 1.18 (0.81-1.72) |
| P | <.001 | .39 |
| Allogeneic HCT (ref no allogeneic HCT) | Not applicable | 0.27 (0.2-0.38) |
| P | <.001 |
Time-dependent Cox regression for RFS; logistic regression for CRMRD−.