TABLE 1.
Clinical and demographic characteristics of patients with pediatric medulloblastoma, 1997–2016
| XRT (n=54) |
PRT (n=64) |
P-value | |
|---|---|---|---|
| Mean age at diagnosis, year (SD) | 8.47 (4.04) | 6.83 (3.20) | 0.02 |
| Sex, n(%) | 0.42 | ||
| Male | 41 (75.9) | 44 (68.8) | |
| Female | 13 (24.1) | 20 (31.3) | |
| Race/Ethnicity, n(%) | 0.37 | ||
| Non-Hispanic White | 19 (35.2) | 29 (45.3) | |
| Hispanic | 19 (35.2) | 23 (35.9) | |
| Non-Hispanic Black | 11 (20.4) | 6 (9.4) | |
| Non-Hispanic Other | 5 (9.3) | 6 (9.4) | |
| CSI radiation dose, n(%)* | 0.24 | ||
| <30 Gy | 40 (74.1) | 40 (63.5) | |
| ≥30 Gy | 14 (25.9) | 23 (36.5) | |
| Treatment Protocol, n(%)* | <0.001 | ||
| SJMB 961 | 22 (40.7) | 0 (0.0) | |
| SJMB 032 | 15 (27.8) | 38 (60.3) | |
| COG AA99613 | 14 (25.9) | 7 (11.1) | |
| SJMB 124 | 0 (0.0) | 9 (14.3) | |
| Other | 3 (5.6) | 9 (14.3) | |
| Diagnosis Year, n(%) | <0.001 | ||
| 1997–2005 | 44 (81.5) | 0 (0.0) | |
| 2006–2016 | 10 (18.5) | 64 (100.0) |
XRT, photon radiation therapy; PRT, proton radiation therapy; SD, standard deviation; CSI, craniospinal irradiation; SJMB, St. Jude Medulloblastoma; COG, Children’s Oncology Group
Data incomplete for CSI radiation dose (n=1) and treatment protocol (n=1).
Per protocol, treated with 23.4 Gy for average-risk disease and 36.0–39.6 Gy for high-risk disease
Per protocol, treated with 23.4 Gy for average-risk disease and 36.0–39.6 Gy for high-risk disease
Per protocol, treated with 23.4 Gy CSI and 55.8 Gy total dose to PF
Radiation dose dependent upon molecular subtype and further risk stratification related to residual disease, histology, and presence of metastasis