TABLE 2.

The role of the Fox subfamilies in osteoclast differentiation.

Fox genes	Expression	Target genes/pathway	Effects on osteoclastogenesis	Cells/animal model	Reference
FoxO1	Decreased	PI3K/AKT	Promoted	Mice with conditional loss	Bartell et al. (2014)
FoxO1	OE	Myc, ERK	Inhibited	RAW264.7 cells	Tan et al. (2015)
FoxO1	Decreased	NFATc1	Promoted	Bone marrow macrophages/RAW264.7 osteoclast precursors	Wang et al. (2015)
FoxM1	KD	RANKL/OPG	Promoted	RAW264.7 cells	Li et al. (2019)
FoxM1	Deletion	RANKL/OPG/RANK	Inhibited	Mice AtoMs	Hasegawa et al. (2019)
FoxP1	OE	INF-γ, MCP-1	Inhibited	FoxP1-overexpressing transgenic mice	Shi et al. (2008)
FoxP3	Increased	RANKL/OPG/RANK and IFNγ	Promoted	Osteoclast precursors	(Zaiss et al., 2007; Zaiss et al., 2010)