REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit monoclonal anti-FoxO1	Cell Signaling Technology	Cat. #2880; RRID: AB_2106495
Rabbit polyclonal anti-ACE2	Abcam	Cat. ab15348; RRID: AB_301861
Rabbit monoclonal anti-β-Actin	Cell Signaling Technology	Cat. #4970; RRID: AB_2223172
Rabbit monoclonal anti-SARS-CoV-2 Nucleocapsid	Sino Biological Company	Cat. # 40143-R001; RRID: AB_2827974
Rabbit monoclonal anti-HA	Cell Signaling Technology	Cat. #3724; RRID: AB_1549585
Mouse monoclonal anti-Flag	Cell Signaling Technology	Cat. #8146; RRID: AB_10950495
Anti-rabbit IgG, HRP-linked Antibody	Cell Signaling Technology	Cat. #7074; RRID: AB_2099233
Bacterial and virus strains
SARS-CoV-2 (hCoV-19/CHN/SYSU-IHV/2020 strain)	Sun Yat-sen University	GISAID: EPI_ISL_444969
AAV9-CAG-humanACE2-EGFP	PackGene Biotech	N/A
AAV9-CAG-mACE2shRNA-EGFP	PackGene Biotech	N/A
Chemicals, peptides, and recombinant proteins
A779	MedChenExpress	Cat. HY-P0216
Amsacrine	MedChenExpress	Cat. HY-13551
Anagrelide	MedChenExpress	Cat. HY-B0523A
AZD-7762	MedChenExpress	Cat. HY-10992
Clebopride	MedChenExpress	Cat. HY-B1613A
Diminazene aceturate (DIZE)	MedChenExpress	Cat. HY-12404
Doxorubicin	MedChenExpress	Cat. HY-15142
DX600	MedChenExpress	Cat. HY-P2222
Entinostat	MedChenExpress	Cat. HY-12163
Harpagoside	MedChenExpress	Cat. HY-N0396
Huperzine-A	MedChenExpress	Cat. HY-17387
Imatinib	MedChenExpress	Cat. HY-15463
Methazolamide	MedChenExpress	Cat. HY-B0553
Ofloxacin	MedChenExpress	Cat. HY-B0125
Pantoprazole	MedChenExpress	Cat. HY-17507
Phensuximide	MedChenExpress	Cat. HY-B(1730)
Pyroxamide	MedChenExpress	Cat. HY-13216
Tranilast	MedChenExpress	Cat. HY-B0195
Xanthone	MedChenExpress	Cat. HY-N0126
Human angiotensin-I converting enzyme 2 (ACE2)	Sino Biological Company	Cat. 10108-H05H
Human IL-4	Sino Biological Company	Cat. 11846-HNAE
Human IL-6	Sino Biological Company	Cat. 10395-HNAE
Human IFN-γ	Sino Biological Company	Cat. 11725-HNAS
Human TNF-α	Sino Biological Company	Cat. 10602-HNAE
Critical commercial assays
Human Angiotensin II ELISA kit	CUSABIO	Cat. CSB-E04493h
Human Angiotensin-(1-7) ELISA kit	CUSABIO	Cat. CSB-E14242h
Mouse TNF-α ELISA kit	CUSABIO	Cat. CSB-E04741m
Mouse IL-6 ELISA kit	CUSABIO	Cat. CSB-E04639m
Mouse Angiotensin II ELISA kit	CUSABIO	Cat. CSB-E04495m
Mouse Angiotensin-(1-7) ELISA kit	CUSABIO	Cat. CSB-E13763m
Mouse kidney injury molecule 1 (KIM-1) ELISA kit	CUSABIO	Cat. CSB-E08809m
Mouse insulin ELISA kit	CUSABIO	Cat. CSB-E05071m
RNA extraction reagent	Accurate Biology Company	Cat. AG21102
Evo M-MLV Reverse Transcription kit	Accurate Biology Company	Cat. AG11711
SYBR Green Premix Pro Taq HS qPCR kit	Accurate Biology Company	Cat. AG11701
ACE2 activity assay Kit (Fluorometric)	Abcam	Cat. ab273297
Triglyceride assay kits	Nanjing Jiancheng Bioengineering Institute	Cat. A110-1-1
Total cholesterol assay kits	Nanjing Jiancheng Bioengineering Institute	Cat. A111-1-1
HDL-C assay kits	Nanjing Jiancheng Bioengineering Institute	Cat. A112-1-1
LDL-C assay kits	Nanjing Jiancheng Bioengineering Institute	Cat. A113-1-1
Series S Sensor Chip CM7	GE Healthcare Life Sciences	Cat. 10281415
Deposited data
Raw RNA-seq data	This paper	GSA: HRA001795
Experimental models: Cell lines
HUVEC	ATCC	CRL-1730; RRID: CVCL_2959
HEK293T	NICR, China	N/A
AML12	ATCC	CRL-2254; RRID: CVCL_0140
Vero E6	ATCC	CRL-1586; RRID: CVCL_0574
Experimental models: Organisms/strains
Mouse: C57BL/6JGpt	GemPharmatech	Cat. N000013; RRID: IMSR_GPT:N000013
Mouse: C57BL/6JGpt ob/ob	GemPharmatech	Cat. T001461; RRID: IMSR_GPT:T001461
Mouse: B6/JGpt-Ace2em1Cin(hACE2)/Gpt	GemPharmatech	Cat. T037659; RRID: IMSR_GPT:T037659
Oligonucleotides
See Table S4 for oligos used in this study	N/A	N/A
Software and algorithms
Graphpad Prism 8	GraphPad Software	N/A
Review Manager 5.4	Cochrane Collaboration	N/A
HISAT2	http://daehwankimlab.github.io/hisat2/	N/A
GENCODE	https://www.gencodegenes.org/	GENCODE 37
DESeq2 package	https://bioconductor.org/packages/release/bioc/html/DESeq2.html	N/A
Metascape	https://metascape.org/	N/A
ImageJ	NIH	N/A
Other
60% High fat diet	Trophic Animal Feed High-Tech Co.,Ltd	Cat. TP23300