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Disruption of central and peripheral rhythms by night-shift work. Under a night-oriented schedule, group rhythms are misaligned relative to the shifted rest-activity cycle and dampened in amplitude. Yellow and gray rectangles represent the environmental light and dark cycles, respectively. Rhythms are adapted from Cuesta et al. (2017) J Biol Rhythms 23; Cuesta et al. (2017); Koshy et al. (2019); Hattammaru et al. (2019). Abbreviation: PBMC = peripheral blood mononuclear cell.
