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. 2022 Feb 7;21:11769351221076062. doi: 10.1177/11769351221076062

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — This is a schematic diagram showing the collection resource for genetic material from various gravitational layers of blood. The genetic material for liquid biopsy can be collected from various body fluids, including blood compartments, ctDNA from plasma, and CTC from buffy coat. Different types of change can be detected as tumor markers from CTC-derived RNA, such as oncogene expression and mutation. ctDNA can be used for the detection of mutations, the promotor methylation of tumor suppressor genes, and the length of DNA fragments.