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. 2022 Feb 11;19:9. doi: 10.1186/s12986-022-00641-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Serum and tissues copper concentrations, redox balance and MG-H1 levels in ND or HFD mice. a Representative photomicrographs of Hematoxylin and Eosin staining in liver sections from representative liver tissues of male mice fed with ND or HFD. Original magnification ×10. b Copper concentration in serum and liver samples of ND and HFD mice. c Transcriptional levels of CTR1, CTR2, ATP7B, COX17, CCS and ATOX1 genes. d Levels of reduced GSH expressed by tGSH/GSSG ratio and d MG-H1 (methyl-glyoxal-hydro-imidazolone) protein adducts. Values are expressed as means ± SD and data were analyzed by a t-Test analysis (*P < 0.05; **P < 0.01; ***P < 0.001)