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. 2022 Feb 10;23:119. doi: 10.1186/s12864-022-08327-9

Table 1.

Identification of cell clusters in the male and female brain of Ae. aegypti

Cluster Cell type Cellular proportion Markers in Ae. aegypti Markers in Drosophila
Female Male Fold (F/M) p value
0 Cluster A 0.0569 0.1286 0.44 P < 0.0001
1 Cluster B 0.0666 0.0723 0.92 P = 0.2638
2 Cluster C 0.0674 0.0711 0.95 P = 0.4674
3 vPN 1 0.0670 0.0450 1.49 P < 0.0001 AAEL019970, AAEL005507, AAEL019457 ct, acj6, Lim 1
4 vPN 2 0.0655 0.0437 1.50 P < 0.0001 AAEL019970, AAEL005507, AAEL019457 ct, acj6, Lim 1
5 Cluster D 0.0397 0.0620 0.64 P < 0.0001
6 Cluster E 0.0479 0.0541 0.88 P = 0.1604
7 Cluster F 0.0279 0.0648 0.43 P < 0.0001
8 Cluster G 0.0412 0.0409 1.01 P = 0.9398
9 Cluster H 0.0387 0.0330 1.17 P = 0.1250
10 KC 1 0.0384 0.0327 1.18 P = 0.1235 AAEL002321, AAEL005834, AAEL019691 eyeless, DopR2, sNPF
11 PN 1 0.0341 0.0329 1.04 P = 0.7391 AAEL019970, AAEL005507 ct, acj6
12 Cluster I 0.0636 0.0056 11.35 P < 0.0001
13 Cluster J 0.0288 0.0357 0.81 P = 0.0521
14 KC 2 0.0372 0.0217 1.72 P < 0.0001 AAEL002321, AAEL005834, AAEL019977 eyeless, DopR2, trio
15 glia 1 0.0275 0.0260 1.06 P = 0.6424 AAEL027131, AAEL010145 repo, nrv2
16 Mi1 0.0284 0.0245 1.16 P = 0.2240 AAEL011643, AAEL007221 hth, bsh
17 Cluster K 0.0292 0.0185 1.58 P = 0.0004
18 Cluster L 0.0217 0.0157 1.38 P = 0.0262
19 Cluster M 0.0213 0.0129 1.65 P = 0.0011
20 Cluster N 0.0176 0.0151 1.16 P = 0.3239
21 Cluster O 0.0249 0.0088 2.84 P < 0.0001
22 astrocyte 0.0165 0.0157 1.05 P = 0.7509 AAEL027131, AAEL007322, AAEL014510 repo, wun2, sty
23 monoaminergic neuron 0.0217 0.0099 2.19 P < 0.0001 AAEL026276, AAEL024732, AAEL005581 Vmat, DAT, SerT
24 Cluster P 0.0150 0.0125 1.20 P = 0.2825
25 Cluster Q 0.0152 0.0119 1.28 P = 0.1526
26 glia 2 0.0032 0.0213 0.15 P < 0.0001 AAEL027131, AAEL010145 repo, nrv2
27 Cluster R 0.0097 0.0153 0.63 P = 0.0126
28 Cluster S 0.0045 0.0162 0.28 P < 0.0001
29 glia 3 0.0067 0.0067 0.99 P = 1.0000 AAEL027131, AAEL010145 repo, nrv2
30 Pm 0.0028 0.0088 0.32 P = 0.0001 AAEL011643, AAEL007120 hth, Lim 3
31 Cluster T 0.0060 0.0039 1.53 P = 0.1325
32 KC 3 0.0017 0.0073 0.24 P < 0.0001 AAEL002321, AAEL005834 eyeless, DopR2
33 glia 4 0.0032 0.0034 0.96 P = 0.8620 AAEL027131, AAEL010145 repo, nrv2
34 vPN 3 0.0021 0.0017 1.28 P = 0.6455 AAEL019970, AAEL005507, AAEL019457 ct, acj6, Lim 1

KC Kenyon cells, Mi1 medulla neurons, Pm proximal medulla neurons, PN projection neurons, vPN ventral projection neurons, Fold (F/M) fold expression (female/male)