Fig. 3.
Significant association results from meta-analyses. The fixed-effect and Stouffer’s p values for the association between SBS1 and CD PRS are p = 4.29 × 10−5 and p = 1.33 × 10−5; for the association between SBS1 and the kidney cancer PRS, they are p = 9.05 × 10−7 and p = 2.10 × 10−4, and for the association between APOBEC-related signatures and IBD PRS, they are p = 2.61 × 10−4 and p = 3.13 × 10−4. There are significant heterogeneities in the effect sizes for the associations between SBS1 and CD PRS and APOBEC-related signatures and IBD PRS across cancers (p < 0.01). The effect sizes and 95% CI for PRS are plotted using gray squares and black horizontal lines. The size of the gray squares represents the weight in the fixed-effect model for each cancer type. Dashed line and diamond represent the results from the fixed-effect model