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Schematic showing mechanism of platelet activation in severely ill COVID-19 patients. An elevated plasma IL-6 and TNFα coexisted with the upregulated pathways like IL-6 and TNF signalling, pro-coagulation and thrombosis, inflammation and ROS metabolism in platelets of ICU patients. Thus, suggesting that these cytokines may be the risk factor for platelet activation and related malady like thrombophilia in these patients.
