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. 2022 Feb 4;119(6):e2111380119. doi: 10.1073/pnas.2111380119

Fig. 7.

Fig. 7.

iASPP-TMCO1 promote tumor growth both in vitro and in vivo. (A) Clone formation of HT-29 or HCT-116 stable lines infected with lentivirus expressing scrambled shRNA (shnone), shiASPP, shTMCO1, or shiASPP+shTMCO1. Relative clone formation ability was quantified and shown in bar graph with shnone normalized to 1. (B–D) Tumor volumes at the indicated time (B), tumor images (C), and tumor weight (C) of HT-29 xenografts and the body weights of nude mice (D) were presented. The average values are present in the graphs (means ± SD) (n = 5 for each pair). (E and F) The representative images of iASPP, TMCO1, and Gp78 proteins (E) and caspase 3/7 activity (F) were determined in the indicated xenografts. β-actin was used as a loading control. Bar graphs represent the mean ± SEM from three independent assays (A and F). *P < 0.05; **P < 0.01; N.S. not significant (A–D, F).