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. 2022 Feb 3;119(6):e2111711119. doi: 10.1073/pnas.2111711119

Fig. 1.

Fig. 1.

Yun is required for ISC proliferation. (A) Yun is required for progenitor proliferation. Quantification of the relative number of esg+ cells in control and yun-depleted intestines (A4). Mean ± SD is shown. ***P < 0.001. (B) Yun is required for ISC proliferation and regeneration. Quantification of ISC clone size of different genotypes (B4). Mean ± SD is shown. ***P < 0.001. (B7) Quantification of the number of pH3 in intestines treated with DSS. Mean ± SD is shown. ***P < 0.001. (C) Yun sustains the proliferation of transformed stem cells. Quantification of the number of pH3 in different genotypes (C5). Mean ± SD is shown. ***P < 0.001. The proliferation of Notch clones (C6) is inhibited by yun depletion (C7). (C8) Quantification of the size of ISC clones. Mean ± SD is shown. ***P < 0.001 (Scale bars, 20 μm).