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. 2022 Feb 3;119(6):e2111711119. doi: 10.1073/pnas.2111711119

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Copyright © 2022 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 3. — Phb2 and Phb1 are required for ISC proliferation. (A) Phb2 and Phb1 are required for progenitor proliferation. Quantification of the esg⁺ cells (ROI) in flies with indicated genotypes (A3). Mean ± SD is shown. ***P < 0.001. Control (B1) and Phb2^Δ (B2) ISC MARCM clones. (B3) Quantification for ISC clone size with indicated genotypes. Mean ± SD is shown. ***P < 0.001. (C) The PHB complex is required for tissue regeneration. Control (C1) and Phb2-depleted (C2) intestines with DSS treatment. (C3) Quantification of the number of pH3 and esg⁺ cells in indicated intestines with DSS treatment. Mean ± SD is shown. ***P < 0.001. (C6) Quantification of the size of ISC clones in indicated intestines after DSS treatment. Mean ± SD is shown. ***P < 0.001. (D) The PHB complex sustains the proliferation of different transformed stem cells. Quantification of the relative number of esg⁺ cells in different genotypes. Mean ± SD is shown. ***P < 0.001. The proliferation of Notch (D4) clones is inhibited by Phb depletion. (D6) Quantification of ISC clone size with indicated genotypes. Mean ± SD is shown. ***P < 0.001 (Scale bars, 20 μm).