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. 2022 Jan 28;8:786682. doi: 10.3389/fnut.2021.786682

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Copyright © 2022 Wu, Mo, Zhang, Zhou and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The intestinal farnesol X receptor (FXR) activity and the expression of genes involved in bile acid recirculation in C57BL/6 mice with different treatments in experiment 2. (A,B) Gene expression levels of FXR and fibroblast growth factor 15 (FGF15) in the ileum. (C) Gene expression level of SHPs in the ileum. (D) Serum FGF15. (E) Gene expression level of apical sodium-dependent BA transporter (ASBT) in the distal ileum. (F–I) Gene expression levels of cytochrome P450 7A1 (CYP7A1), CYP8B1, CYP27A1, and CYP7B1 in the liver. LPS, a LPS injection group that oral gavaged with physiological saline before i.p. LPS injection; GSP + LPS, a GSP administration group that oral gavaged with 250 mg/kg GSP before i.p. LPS injection; Gly + GSP + LPS, the GSP + LPS group coupled with a dose of 10 mg/kg BW glycine-β-muricholic acid. Data are presented by the mean ± SEMs (n = 6). Bars with no letter in common are significantly different, p ≤ 0.05.