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. 2022 Jan 28;8:786682. doi: 10.3389/fnut.2021.786682

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Copyright © 2022 Wu, Mo, Zhang, Zhou and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of CDCA and LCA on C57BL/6 mice injected with LPS in Experiment 3. (A) Serum lipopolysaccharide (LPS), (B) diamine oxidase (DAO), (C–E) serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-6, and (F–H) the ileal inflammatory cytokine gene expression of TNF-α, IL-1β and IL-6. (I,J) Gene expression levels of FXR and fibroblast growth factor 15 (FGF15) in the ileum. (K) Gene expression level of SHPs in the ileum. (L) Serum FGF15. LPS, a LPS injection group that oral gavaged with physiological saline before i.p. LPS injection; BA + LPS, a CDCA and LCA administration group that oral gavaged with a mixture of CDCA and LCA before i.p. LPS injection; Gly + BA + LPS, the BA + LPS group coupled with a dose of 10 mg/kg BW glycine-β-muricholic acid. Data are presented by the mean ± SEMs (n = 6). Bars with no letter in common are significantly different, p ≤ 0.05.