. 2022 Jan 28;8:786682. doi: 10.3389/fnut.2021.786682

Table 1.

Hepatic BA profiles of mice in Experiment 1.

Variable (nmol/g)	Control^a	LPS	GSP + LPS	Abx + GSP + LPS	p -value
Total bile acid	2, 575, 160^b	2, 744, 189^b	2, 514, 173^b	5, 157, 547^a	<0.01
Unconjugated bile acid	107, 11.3	92.6, 8.91	115, 12.2	116, 9.40	0.39
Conjugated bile acid	2, 468, 151^b	2, 652, 192^b	2, 399, 161^b	5, 041, 547^a	<0.01
Cholic acid	8.11, 0.69^a	7.63, 0.99^a	6.37, 0.73^a	1.82, 0.21^b	<0.01
Chenodeoxycholic acid	0.20, 0.04^b	0.19, 0.05^b	0.63, 0.08^a	0.25, 0.06^b	<0.01
ω-muricholic acid	18.7, 2.53^a	17.1, 0.62^a	16.8, 2.11^a	9.19, 0.85^b	<0.01
α-muricholic acid	10.0, 1.75^a	11.5, 1.77^a	12.1, 1.33^a	4.57, 0.62^b	<0.01
β-muricholic acid	53.2, 10.4^b	46.8, 7.72^b	56.7, 8.26^b	86.2, 8.58^a	0.02
Deoxycholic acid	0.21, 0.03^a	0.19, 0.05^a	0.20, 0.03^a	0.02, 0.00^b	<0.01
Lithocholic acid	0.04, 0.01^b	0.03, 0.01^bc	0.10, 0.02^a	0.01, 0.00^c	<0.01
Ursodeoxycholic acid	0.80, 0.09	0.69, 0.09	0.85, 0.12	0.53, 0.17	0.28
Taurocholic acid	377, 54.9^b	386, 29.9^b	340, 43.7^b	787, 74.5^a	<0.01
Taurochenodeoxycholic acid	44.9, 6.13^b	45.5, 4.91^b	78.9, 6.34^a	52.4, 8.65^b	<0.01
Tauro-ω-muricholic acid	186, 39.8	167, 26.6	160, 22.4	134, 16.2	0.62
Tauro-α-muricholic acid	143, 13.0	138, 26.6	128, 18.4	119, 18.9	0.83
Tauro-β-muricholic acid	1, 216, 154^b	1, 584, 205^b	1, 370, 150^b	3, 649, 523^a	<0.01
Taurodeoxycholic acid	98.9, 8.89^a	93.3, 10.5^a	109, 9.06^a	0.65, 0.27^b	<0.01
Taurolithocholic acid	4.94, 0.50^b	4.51, 0.37^b	8.19, 0.61^a	0.53, 0.12^c	<0.01
Tauroursodeoxycholic acid	59.0, 9.02	70.7, 6.17	66.1, 7.35	84.7, 17.0	0.41

^a−c

In each row, means with the same letter represented no significant differences.

^aControl, control group that oral gavaged with physiological saline before i.p. PBS injection; LPS, a LPS injection group that oral gavaged with physiological saline before i.p. LPS injection; GSP + LPS, a GSP administration group that oral gavaged with 250 mg/kg GSP before i.p. LPS injection; Abx + GSP + LPS, an antibiotic group that given a mixture of antibiotics in drinking water before the Experiment 1, and then coupled with GSP before i.p. LPS injection. n = 6.

BA, bile acid.