. 2022 Jan 28;8:786682. doi: 10.3389/fnut.2021.786682

Table 2.

Fecal BA profiles of mice in Experiment 1.

Variable (nmol/g)	Control^a	LPS	GSP + LPS	Abx + GSP + LPS	p -value
Total bile acid	547, 45.8^ab	621, 49.9^a	583, 21.2^a	447, 39.6^b	0.03
Unconjugated bile acid	539, 44.8^ab	608, 49.7^a	571, 21.3^a	430, 38.6^b	0.02
Conjugated bile acid	8.21, 1.12^c	13.2, 1.26^b	11.9, 1.34^b	17.3, 1.17^a	<0.01
Cholic acid	71.6, 2.80^a	78.5, 10.3^a	57.1, 10.9^a	28.5, 4.73^b	<0.01
Chenodeoxycholic acid	4.57, 0.88^b	7.89, 0.86^b	22.9, 3.01^a	3.75, 0.72^b	<0.01
ω-muricholic acid	158, 22.8	194, 28.2	144, 18.0	170, 23.9	0.52
α-muricholic acid	55.2, 5.73^ab	70.4, 5.47^a	63.9, 7.96^ab	46.3, 7.28^b	0.09
β-muricholic acid	77.5, 8.32	97.1, 12.4	90.8, 13.3	119, 16.3	0.19
Deoxycholic acid	85.7, 8.79^a	106, 9.86^a	92.1, 8.59^a	28.5, 5.25^b	<0.01
Lithocholic acid	11.1, 1.29^b	13.2, 0.75^b	47.4, 5.10^a	5.56, 2.40^b	<0.01
Ursodeoxycholic acid	6.39, 0.92^b	8.07, 1.47^ab	9.99, 0.48^a	1.77, 0.44^c	<0.01
Taurocholic acid	2.87, 0.71^b	3.26, 0.62^b	2.01, 0.25^b	7.43, 0.54^a	<0.01
Taurochenodeoxycholic acid	0.16, 0.02^b	0.17, 0.07^b	0.29, 0.06^b	0.52, 0.07^a	<0.01
Tauro-ω-muricholic acid	2.31, 0.22^b	3.71, 0.49^a	3.55, 0.37^ab	4.43, 0.54^a	0.02
Tauro-α-muricholic acid	2.17, 0.19^b	3.44, 0.38^ab	3.18, 0.52^ab	3.85, 0.48^a	0.06
Tauro-β-muricholic acid	0.02, 0.00^b	0.03, 0.01^b	0.03, 0.01^b	0.27, 0.03^a	<0.01
Taurodeoxycholic acid	0.30, 0.06^b	0.49, 0.08^ab	0.58, 0.16^a	0.01, 0.00^c	<0.01
Taurolithocholic acid	0.06, 0.01^b	0.09, 0.02^b	0.16, 0.03^a	0.01, 0.00^c	<0.01
Tauroursodeoxycholic acid	0.11, 0.02^a	0.14, 0.02^a	0.13, 0.02^a	0.00, 0.00^b	<0.01

^a−c

In each row, means with the same letter represented no significant differences.

^aControl, control group that oral gavaged with physiological saline before i.p. PBS injection; LPS, a LPS injection group that oral gavaged with physiological saline before i.p. LPS injection; GSP + LPS, a GSP administration group that oral gavaged with 250 mg/kg GSP before i.p. LPS injection; Abx + GSP + LPS, an antibiotic group that given a mixture of antibiotics in drinking water before the Experiment 1, and then coupled with GSP before i.p. LPS injection. n = 6–7.

BA, bile acid.