|
Gene
|
Protein name
|
Gene bank accession number
|
Function
|
| WNT7B [56, 57] |
Wnt7b protein |
AY400071 |
WNT7B is involved in tumor growth promotion, immunosuppression, angiogenesis, and cancer cell dissemination. |
| LEF1 [58] |
Lymphoid enhancer binding factor 1 |
AY129650 |
LEF1 regulates glutathione metabolism, increases chemotherapy resistance, and promotes breast cancer brain metastasis. |
| BCL2A1 [59, 60] |
BCL2 related protein A1 |
DQ081729 |
BCL2A1 represses hypoxia-induced cell death and mitochondria-mediated apoptosis and promotes tumor growth and metastasis. |
| ULBP2 [61, 62] |
UL16 binding protein 2 |
AY358665 |
ULBP2 increases NK cell cytotoxicity resistance and promotes cervical cancer proliferation, invasion, and migration. |
| GABRQ [63, 64] |
Gamma-aminobutyric acid type A receptor subunit theta |
KJ899212 |
GABRQ promotes hepatocellular cancer cell proliferation. |
| FXYD3 [65] |
FXYD domain containing ion transport regulator 3 |
KJ891826 |
FXYD3 promotes breast cancer cell proliferation. |
| SCG2 [66] |
Secretogranin II |
KJ897788 |
SCG2 enhances endothelial angiogenesis. |
| FOXJ1 [67–70] |
Forkhead box J1 |
KJ891181 |
FOXJ1 promotes bladder cancer, prostate cancer, hepatocellular cancer, and gastric cancer growth, and metastasis. |
| TP63 [71] |
Tumor protein p63 |
KR711025 |
TP63 increases expression of epidermal growth factor receptor in breast cancer and increases the response of breast cancer to cisplatin. |
| RYR1 [72] |
Ryanodine receptor 1 |
AH006668 |
RYR1 plays a vital role as a calcium channel in excitation-contraction coupling in muscle. |
| FEZ1 [73–76] |
Fasciculation and elongation protein zeta 1 |
AF123653 |
FEZ1 suppresses prostate, esophageal, gastric, bladder, and breast cancer progression, and mediates promoter methylation-mediated transcriptional downregulation and mitosis inhibition. |
| NRG1 [77] |
Neuregulin 1 |
CR450288 |
Heregulin isoforms encoded by NRG1 promote tumor growth and induce metastasis. |
| NFE2 [78] |
Nuclear factor, erythroid 2 |
CR450284 |
NFE2 promotes breast cancer cell growth in the bone microenvironment, which leads to bone metastasis; enhances expression of Wnt-related molecules. |
| HOXC13 [79] |
Homeobox C13 |
AF263466 |
HOXC13 facilitates cervical cancer cell proliferation, migration, invasion and glycolysis through the β-catenin/c-Myc signaling pathway. |
| MMP25 [80] |
Matrix metallopeptidase 25 |
HF584190 |
High expression of MMP25 in head and neck cancer is associated with a worse prognosis; MMP25 is related to apoptosis, the KRS signaling pathway, the PI3K/AKT/mTOR signaling pathway, and the JAK/STAT signaling pathway. |
| DTX1 [81, 82] |
Deltex E3 ubiquitin ligase 1 |
KT584324 |
DTX1 is a regulator of the Notch signaling pathway and acts as an E3 ubiquitin ligase that can repress Notch gene expression and inhibit early-stage non-small cell lung carcinoma growth. |
