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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Pharmacol Biochem Behav. 2022 Jan 19;213:173337. doi: 10.1016/j.pbb.2022.173337

Figure 2. Behavioral data for aged mice on experimental diet.

Figure 2.

(A) Experimental timeline. All behavior is plotted as fold change (post-experimental diet normalized to baseline performance at 12 months). (B) Change in body weight was not affected by diet. YAC128 mice were heavier and gained more weight over time in females only. (C) Fold change in the time spent in the open zone of the EZM. The decrease in time spent in the open zone was greater in female YAC128 mice compared to WT, with no effect of high Mn diet in any group. (D) Fold change in distance travelled during the EZM task was unaffected by high Mn diet in both sexes, but the change in distance travelled was greater in YAC128 than WT in females only. (E) Fold change in the total distance travelled during 30 min in locomotor activity chambers. No effects of high Mn diet but again the decrease in activity was greater in YAC128 females than WT females. (F) Fold change in rotarod performance was significantly different between WT and YAC128 in females only, with no effect of high Mn diet in either sex. (G) Fold change in grip strength was comparable among all groups. For all, mean ± S.E.M. plotted unless otherwise noted. n=7-9 per genotype-diet group for females and n=3-7 for males. *P <0.05, *Pp<0.01, ***P<0.001 indicates main effect of genotype.