Fig. 4.

Comparison of initial decay rates for plasma virus and intact proviruses. Lines show fractional decrease in plasma virus (solid lines) and intact proviruses (dotted lines) between the baseline (pre-ART) timepoint and the first on-ART time point 2 to 3 wk later. For some participants, the first on-ART plasma virus measurement was below the limit of detection (BLD; open circles), and it is likely that the initial decay slope is even steeper than that shown. Samples were not available to measure early proviral decay in participants 441 and 447. Participant 460 had an unusual IPDA dot plot pattern suggestive of multiple expanded clones (SI Appendix, Fig. S2) and was not included in the analysis of proviral decay for that reason.