Figure 1.

Signal transduction pathway activity in CD4+ T cells from matched blood, lymph nodes (LNs), and tumor-infiltrating (TIL) samples of 10 patients with invasive breast cancer (BrCa) and four healthy donors (dataset GSE36765) [19]. From left to right: FOXO, NFκB, JAK-STAT1/2, JAK-STAT3, TGFβ, and Notch pathway activity scores. The pathway activity is indicated as log2 odds on the y-axis. For each individual patient, the sample pathway scores are connected by colored lines (“pt” for BrCa patient samples; “d” for healthy donor samples). p-values (two-sided Wilcoxon-test) are listed when significant (p < 0.05); a paired test was performed when comparing results amongst BrCa samples.