Table 3.
Characteristics and outcome of incident colorectal cancer in the tested IBD population.
| Total (n = 56) | UC (n = 34) | CD (n = 22) | p (Yates) | |
|---|---|---|---|---|
| CRC Site, n (%) | ||||
| Rectum | 24 (42.8%) | 15 (44.2%) | 9 (40.9%) | 0.96 |
| Sigmoid colon | 10 (17.9%) | 8 (23.7%) | 2 (9.1%) | 0.30 |
| Left colon | 5 (8.9%) | 4 (11.7%) | 1 (4.5%) | 0.65 |
| Transverse colon | 4 (7.1%) | 4 (11.7%) | 0 (0%) | 0.25 |
| Right colon | 8 (14.3%) | 2 (5.8%) | 6 (27.4%) | 0.06 |
| Cecum | 2 (3.6%) | 1 (2.9%) | 1 (4.5%) | 0.67 |
| Ileo-cecal valve | 2 (3.6%) | 0 (0%) | 2 (9.1%) | 0.29 |
| Anal canal/rectal edge | 1 (1.8%) | 0 (0%) | 1 (4.5%) | 0.82 |
| Left vs. Right Colon, n (%) | ||||
| Left Colon | 40 (71.4%) | 27 (79.4%) | 13 (59.1%) | 0.17 |
| Right colon | 16 (28.6%) | 7 (20.6%) | 9 (40.9%) | 0.17 |
| CRC Histotype, n (%) | ||||
| Adenocarcinoma | 51 (91%) | 30 (88.4%) | 21 (95.5%) | 0.65 |
| Squamous carcinoma | 1 (1.8%) | 1 (2.9%) | 0 (0%) | 0.82 |
| Epidermoid | 1 (1.8%) | 1 (2.9%) | 0 (0%) | 0.82 |
| Neuroendocrine | 2 (3.6%) | 1 (2.9%) | 1 (4.5%) | 0.67 |
| N/A | 1 (1.8%) | 1 (2.9%) | 0 (0%) | 0.82 |
| CRC-Related Symptoms, n (%) | 29 (51.9%) | 19 (55.9%) | 10 (45.4%) | 0.62 |
| Rectal bleeding | 13 (23.6%) | 10 (29.4%) | 3 (13.6%) | 0.29 |
| Abdominal pain | 10 (17.8%) | 5 (14.7%) | 5 (22.7%) | 0.68 |
| Refractory IBD | 5 (8.9%) | 4 (11.7%) | 1 (4.5%) | 0.65 |
| Diarrhea | 4 (7.1%) | 1 (2.9%) | 3 (13.6%) | 0.32 |
| Occlusion | 3 (5.3%) | 2 (5.8%) | 1 (4.5%) | 0.69 |
| Change in bowel habits | 3 (5.3%) | 2 (5.8%) | 1 (4.5%) | 0.69 |
| CRC Diagnosis, n (%) | ||||
| Colonoscopy | 40 (71.4%) | 29 (85.4%) | 11 (50%) | 0.01 |
| Imaging | 9 (16.1%) | 2 (5.8%) | 7 (31.8%) | 0.02 |
| Intra-operatory | 7 (12.5%) | 3 (8.8%) | 4 (18.2%) | 0.53 |
| CRC and Concomitant Adenoma, n (%) | 4 (7.1%) | 4 (11.7%) | 0 (0%) | 0.25 |
| Surgical/Endoscopic Treatment, n (%) | 51 (91.1%) | 30 (88.2%) | 21 (95.5%) | 0.65 |
| Palliative stoma | 3 (5.9%) | 3 (10%) | 0 (0%) | 0.40 |
| Endoscopic removal | 3 (5.9%) | 1 (3.3%) | 2 (9.5%) | 0.69 |
| Anterior Rectal Resection | 1 (1.9%) | 0 (0%) | 1 (4.7%) | 0.82 |
| Ileo-colonic resection | 1 (1.9%) | 1 (3.3%) | 0 (0%) | 0.82 |
| Hemicolectomy | 6 (11.8%) | 0 (0%) | 6 (28.6%) | 0.006 |
| Colectomy + colostomy | 3 (5.9%) | 1 (3.3%) | 2 (9.5%) | 0.69 |
| Colectomy + ileostomy | 16 (31.4%) | 8 (26.7%) | 8 (38.1%) | 0.46 |
| Ileal pouch | 9 (17.6%) | 9 (30%) | 0 (0%) | 0.02 |
| Ileo-rectal anastomosis | 9 (17.6%) | 7 (23.3%) | 2 (9.5%) | 0.44 |
|
CRC-Related Death, n (%) Yes |
16 (28.5%) | 10 (29.4%) | 6 (27.2%) | 0.89 |
| No | 36 (64.3%) | 22 (64.8%) | 14 (63.7%) | |
| Unknown | 4 (7.1%) | 2 (5.8%) | 2 (9.1%) | |
| Non-CRC Related Death, n (%) | 2 (3.6%) | 0 (0%) | 2 (9.1%) | 0.29 |
| Death (Overall), n (%) | 18 (32.1%) | 10 (29.4%) | 8 (36.4%) | 0.80 |
| Lost at Follow-Up, n (%) | 20 (35.7%) | 13 (38.2%) | 7 (31.8%) | 0.83 |
Abbreviations. IBD: Inflammatory Bowel Disease; UC: Ulcerative Colitis; CD: Crohn’s Disease; CRC: colorectal cancer; N/A: not applicable.