Table 2.
Overview of trials including patients with salvage prostate or prostate bed SBRT with prior radiotherapy (data below for included patients with prostate bed RT) (n = 8).
| Trial | Year of Publication | Years of RT | Target | Number of Patients Included | Type of Trial | RT Technique | Radiotherapy Dose | Median FU | Dose Previous RT (Median) | Time between RT |
|---|---|---|---|---|---|---|---|---|---|---|
| Detti et al. [52] | 2016 | 2011–2013 | Macroscopic recurrence | 16 | retrospective analysis of prospectively collected data | Cyberknife | 5 × 6 Gy (@80% IDL) for re-RT | 10 months | Median 66 Gy (range 64 Gy–70 Gy) | mean 9.6 years (2.9–20.4 years) |
| 5 × 7 Gy (@80% IDL) for RT-naïve | ||||||||||
| Alternating days | ||||||||||
| Olivier et al. [56] | 2019 | 2011–2017 | Macroscopic recurrence | 12 | retrospective | Cyberknife | 6 × 6 Gy (@80% IDL) | 34.2 months | 66 Gy (11 pts) | median 77.6 months (range 21.4–160.8 months) |
| Alternating days | 72 Gy (1 pt) | |||||||||
| Caroli et al. [51] | 2020 | 2016–2018 | Not reported | 38 | retrospective analysis of prospectively collected data | not reported | 3 × 6 Gy | 27 months | not reported | not reported |
| (IQR 18–21 Gy) | ||||||||||
| Arcangeli et al. [49] | 2015 | not reported presumed 2014 | Macroscopic recurrence | 1 | case report | Tomotherapy | 5 × 6 Gy | 6 months | 66 Gy | Appr. 4 years |
| Consecutive days | ||||||||||
| Scher et al. [58] | 2019 | 2014–2017 | Macroscopic recurrence | 9 (42, 21.4%) | retrospective | Cyberknife | 6 × 6 Gy Alternating days | 17 months | 68 Gy (65–70 Gy) | 128 months (54–207 months) |
| Jereczek-Fossa et al. [55] | 2018 | 2009–2016 | Macroscopic recurrence | 19 (64, 29.7%) | retrospective | Cyberknife, Rapid Arc, Vero | 5 × 5–6 Gy (median 25 Gy/5 Fx) | 26.1 months | 70 Gy (45–77.4 Gy) | 93.9 months (27.9–183.3 months) |
| Alternating days | ||||||||||
| Zerini et al. [59] | 2015 | 2008–2013 | Macroscopic recurrence | 10 (32, 31.3%) | retrospective | 3D CRT (conformal dynamic arc), RA, Vero, Cyberknife | 15–25 Gy/3–5 Fx | 21.3 months (all patients) | 73 Gy (60–83 Gy) all patients | not reported |
| (median 25 Gy/5 Fx) | ||||||||||
| Alternating days (?) | ||||||||||
| Janoray et al. [54] | 2016 | 2011–2014 | Macroscopic recurrence | 10 (21, 48%) | retrospective | Cyberknife | 5 × 7.25 Gy (@80% IDL) Alternating or consecutive days | 11.7 months (all patients) | median 70 Gy (45–76 Gy) | 98.03 months |