Table 1.

Hormone and GF-dependent regulation of HIF expression/signaling (↑is increase, ↓is decrease).

Signaling	Cancer	Response	Reference
ERα-mediated estrogen signaling	Ovarian	↑ HIF-1α protein/signaling	[180]
	Thyroid	↑ HIF-1α protein	[183]
	Breast	↑ HIF-1α protein/signaling	[184]
	Breast	↓ HIF-2α mRNA/protein	[186]
	Breast	↑ HIF-1α mRNA	[192]
GPER-mediated estrogen signaling	Breast, CAFs	↑ HIF-1α mRNA/protein/signaling	[155]
EGF/EGFR signaling	Prostate	↑ HIF-1α protein/signaling	[199]
	NSCLC	↑ HIF-1α signaling	[200]
	Breast	↑ HIF-1α protein/signaling	[201,203]
	Colorectal	↑ HIF-1α mRNA/protein	[202]
Heregulin	Breast	↑ HIF-1α protein/signaling	[174]
IGF-I	Colon	↑ HIF-1α protein/signaling	[175]
	NSCLC, HNSCC	↑ HIF-1α protein/signaling	[219]
	Kaposi sarcoma	↑ HIF-1α and HIF-2α protein/signaling	[220]
	Breast	↑ HIF-1α and HIF-2α protein/signaling	[221,222,223]
bFGF	Breast	↑ HIF-1α protein/signaling	[176,230,231]