Table 3.
PET characteristics based on the physiologic [18F]FDG-uptake in the location of the extranodal lesion.
| Caption | All Studies | Studies with Extranodal Lesion Located in Tissues with High/Heterogeneous Physiologic [18F]FDG-Uptake | Studies with Extranodal Lesion Located in Tissues with Low/Homogeneous Physiologic [18F]FDG-Uptake | p | |
|---|---|---|---|---|---|
| Extranodal lesion | DR: | 38/66 (57.6%) | 19/47 (40.4%) | 19/19 (100%) | <0.01 |
| SUVmax | 7.1 (4.8–9.3) | 7.9 (4.9–11.2) | 6.8 (4.3–9.1) | 0.25 | |
| MTV | 5.5 (3.2–22.5) | 5.4 (3.0–12.1) | 11.7 (3.6–28) | 0.40 | |
| TLG | 25.6 (11.4–100.7) | 22.8 (10.4–57.8) | 47.9 (11.7–112.2) | 0.71 | |
| Nodal lesion | DR: | 13/66 (19.7%) | 9/47 (19.9%) | 4/19 (21.1%) | 0.86 |
Categorical variable is reported as frequency and percentage. Continuous variables are reported as median and IQR. High/heterogeneous physiologic [18F]FDG-uptake, refers to gastrointestinal tract, orbit, head and neck, urinary bladder. Low/homogenous physiologic [18F]FDG-uptake, refers to subcutaneous-tissue, breast, lung, liver. SUVmax, MTV and TLG were calculated in the “hottest” extranodal and “hottest” nodal lesions, only if identified on PET. DR, detection rate; SUVmax, maximum standardized uptake value; MTV, metabolic tumor volume; TLG, total lesion glycolysis.