Table 5.
Comparison of patients’ characteristics based on extranodal lesion’s PET characteristics.
| Variable | Extranodal Lesion Not Detected on PET (n = 28) | Extranodal Lesion with Low [18F]FDG-Avidity (n = 19) | Extranodal Lesion with High [18F]FDG-Avidity (n = 19) | p |
|---|---|---|---|---|
| Stage I | 21/28 (75%) | 9/19 (47.4%) | 7/19 (36.8%) | 0.02 (a) |
| Stage IV | 7/28 (25%) | 10/19 (52.6%) | 12/19 (63.2%) | 0.02 (a) |
| B symptoms | 3/24 (12.5%) | 0/17 (0%) | 3/17 (17.6%) | 0.10 |
| Bulky disease | 0/28 (0%) | 5/19 (26.3%) | 6/19 (31.6%) | <0.01 (a)(b) |
| BM involvement | 1/20 (5%) | 1/11 (9.1%) | 6/14 (42.9%) | 0.02 (a) |
| Nodal involvement | 7/28 (25%) | 6/19 (31.6%) | 9/19 (47.4%) | 0.28 |
| High Ki-67 index | 1/21 (4.8%) | 0/15 (0%) | 1/17 (5.9%) | 0.50 |
| High serum LDH | 0/25 (0%) | 3/16 (18.8%) | 0/16 (0%) | 0.02 (b) |
| Anemia | 6/18 (33.3%) | 4/15 (26.7%) | 4/15 (26.7%) | 0.88 |
| Thrombocytopenia | 1/18 (5.6%) | 1/13 (7.7%) | 2/15 (13.3%) | 0.73 |
| [18F]FDG-avid nodal disease | 3/28 (10.7%) | 2/19 (10.5%) | 8/19 (42.1%) | 0.02 (c) |
Categorical variables are reported as frequency and percentage. Continuous variables are reported as median and IQR. [18F]FDG-avidity was considered high if SUVmax was > median SUVmax. Bulky disease, positive if any lymphoma lesion >5 cm in any dimension; Nodal involvement, positive if any lymph node was considered involved in the disease (not necessarily [18F]FDG-avid); BM involvement, positive if lymphoma was identified on BM aspirate or biopsy or flow cytometric immunophenotyping; High Ki-67 index, positive if reported >20%; High serum LDH, positive if >380 U/l; Anemia, positive if hemoglobin <12.5 g/dL for female or <13.5 g/dL for male patient; Thrombocytopenia, positive if platelets count <150,000 platelets per microliter; BM, bone marrow; LDH, lactate dehydrogenase; (a), significant difference between the 1st and 3rd column; (b), significant difference between the 1st and 2nd column; (c), significant difference between the 2nd and 3rd column.