Table 2.
Comparison of baseline clinical characteristics between patients with HCC and without.
| Variables | No HCC (n = 2723) | HCC (n = 303) | p Value |
|---|---|---|---|
| Age (year) | 49 (41, 56) | 55 (51, 60) | <0.001 |
| Male | 1633 (60.0) | 222 (73.3) | <0.001 |
| Cirrhosis | 1150 (42.2) | 241 (79.5) | <0.001 |
| Diabetes mellitus | 453 (16.6) | 94 (31.0) | <0.001 |
| Hypertension | 415 (22.1) | 105 (42.5) | <0.001 |
| Positive for HBeAg | 973 (35.7) | 72 (23.8) | <0.001 |
| Total bilirubin (mg/dL) | 0.80 (0.60, 1.10) | 0.90 (0.65, 1.30) | 0.053 |
| Serum albumin (g/dL) | 4.2 (3.9, 4.4) | 4.0 (3.5, 4.3) | <0.001 |
| Platelet count (×109/L) | 167 (127, 213) | 122 (90, 159) | <0.001 |
| Prothrombin time (INR) | 1.03 (0.97, 1.10) | 1.07 (1.00, 1.16) | <0.001 |
| AST (IU/L) | 50 (32, 93) | 50 (36, 86) | 0.490 |
| ALT (IU/L) | 55 (30, 119) | 48 (30, 87) | 0.005 |
| Liver stiffness (kPa) | 7.70 (5.30, 13.10) | 14.30 (9.30, 22.15) | <0.001 |
| FIB-4 | 2.11 (1.25, 3.56) | 3.38 (2.19, 5.76) | <0.001 |
| APRI | 0.84 (0.46, 1.68) | 1.09 (0.66, 2.06) | <0.001 |
| PAGE-B | 13 (10, 16) | 18 (15, 19) | <0.001 |
| Modified PAGE-B | 11 (8, 13) | 13 (12, 15) | <0.001 |
| Modified REACH-B | 8 (6, 10) | 11 (9, 12) | <0.001 |
| LSM-HCC | 13 (6, 19) | 23 (16, 25) | <0.001 |
| CAMD | 10 (7, 14) | 16 (13, 17) | <0.001 |
| FSAC | 5 (2, 9) | 10 (8, 11) | <0.001 |
Values are expressed as a number (percentage) or median (interquartile range). Abbreviations: HCC, hepatocellular carcinoma; HBeAg, hepatitis B e antigen; AST, aspartate aminotransferase; ALT, alanine aminotransferase.